coli and are therefore unlikely to support phage integration. Two of the other potential sites lie within genes predicted to be essential to E. coli genome, and three of these were confirmed experimentally. An additional six potential integration sites were identified in the E. coli int gene was identified close to the Phi24(B) integration site, it was shown not to be involved in the phage integration event. Here, the Phi24(B) integrase gene is identified, and the preferred site of integration defined. However, contrary to the lambda superinfection immunity model, it has been demonstrated that double lysogens can be produced with the Stx-phage Phi24(B). It had been assumed that Stx-phages would behave similarly to lambda phage. The key virulence factor in Shiga-toxigenic Escherichia coli is the expression of Shiga toxin (Stx), which is conferred by Stx-encoding temperate lambdoid phages (Stx-phages).
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